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1

DETECTION OF L-DNA IN STOOL SAMPLES, USING DENATURING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (DHPLC): A NON INVASIVE TOOL FOR THE DIAGNOSIS OF COLORECTAL CANCER. PRELIMINARY REPORT

M. Cretella, G. Del Vecchio Blanco, M. Kalimutho, P. Gravina, A. Caruso, E. Mannisi, M. Cossignani, P. Sileri, S. Bernardini, F. Pallone

Journal:

Digestive and Liver Disease

Year:

2009

Language:

english

File:

PDF, 68 KB

english, 2009

2

Targeted Therapies for Triple-Negative Breast Cancer: Combating a Stubborn Disease

Kalimutho, Murugan, Parsons, Kate, Mittal, Deepak, López, J. Alejandro, Srihari, Sriganesh, Khanna, Kum Kum

Journal:

Trends in Pharmacological Sciences

Year:

2015

Language:

english

File:

PDF, 5.07 MB

english, 2015

3

Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling

Sinha, Debottam, Kalimutho, Murugan, Bowles, Josephine, Chan, Ai-Leen, Merriner, D. Jo, Bain, Amanda L., Simmons, Jacinta L., Freire, Raimundo, Lopez, J. Alejandro, Hobbs, Robin M., O’Bryan, Moira K.,

Journal:

The FASEB Journal

Year:

2018

Language:

english

File:

PDF, 3.99 MB

english, 2018

4

Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti‐PD‐L1 antibody for treatment of triple‐negative breast cancer

Raninga, PV, Lee, A, Sinha, D, Shih, YY, Mittal, D, Makhale, A, Bain, A, Nanayakarra, D, Tonissen, KF, Kalimutho, M, Khanna, KK

Journal:

International Journal of Cancer

Year:

2019

Language:

english

File:

PDF, 3.45 MB

english, 2019

5

Satraplatin (JM-216) mediates G2/M cell cycle arrest and potentiates apoptosis via multiple death pathways in colorectal cancer cells thus overcoming platinum chemo-resistance

Murugan Kalimutho, Antonella Minutolo, Sandro Grelli, Amanda Formosa, Giulia Sancesario, Alessandra Valentini, Giorgio Federici, Sergio Bernardini

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2011

Language:

english

File:

PDF, 617 KB

english, 2011

6

A simplified, non-invasive fecal-based DNA integrity assay and iFOBT for colorectal cancer detection

Murugan Kalimutho, Giovanna Del Vecchio Blanco, Micaela Cretella, Elena Mannisi, Pierpaolo Sileri, Amanda Formosa, Francesco Pallone, Giorgio Federici, Sergio Bernardini

Journal:

International Journal of Colorectal Disease

Year:

2011

Language:

english

File:

PDF, 272 KB

english, 2011

7

Differential expression of miR-144* as a novel fecal-based diagnostic marker for colorectal cancer

Murugan Kalimutho, Giovanna Del Vecchio Blanco, Serena Di Cecilia, Pierpaolo Sileri, Micaela Cretella, Francesco Pallone, Giorgio Federici, Sergio Bernardini

Journal:

Journal of Gastroenterology

Year:

2011

Language:

english

File:

PDF, 546 KB

english, 2011

8

Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer

Kalimutho, M, Di Cecilia, S, Del Vecchio Blanco, G, Roviello, F, Sileri, P, Cretella, M, Formosa, A, Corso, G, Marrelli, D, Pallone, F

Journal:

British Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 461 KB

english, 2011

9

OP 16 Identification of JAK2/STAT3 as a novel therapeutic target in Kras mutant colorectal cancer models

M. Kalimutho, R. Carson, P. Dunne, D. Longley, P. Johnston, S. Van Schaeybroeck

Journal:

European Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 52 KB

english, 2011

10

AXL Is a Key Regulator of Inherent and Chemotherapy-Induced Invasion and Predicts a Poor Clinical Outcome in Early-Stage Colon Cancer

Dunne, P. D., McArt, D. G., Blayney, J. K., Kalimutho, M., Greer, S., Wang, T., Srivastava, S., Ong, C. W., Arthur, K., Loughrey, M., Redmond, K., Longley, D. B., Salto-Tellez, M., Johnston, P. G., Va

Journal:

Clinical Cancer Research

Year:

2014

Language:

english

File:

PDF, 1.20 MB

english, 2014

11

Natural Killer Cells Are Essential for the Ability of BRAF Inhibitors to Control BRAFV600E-Mutant Metastatic Melanoma

Ferrari de Andrade, L., Ngiow, S. F., Stannard, K., Rusakiewicz, S., Kalimutho, M., Khanna, K. K., Tey, S.-K., Takeda, K., Zitvogel, L., Martinet, L., Smyth, M. J.

Journal:

Cancer Research

Year:

2014

Language:

english

File:

PDF, 1.40 MB

english, 2014

12

Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer

Al-Ejeh, F, Simpson, P T, Saunus, J M, Klein, K, Kalimutho, M, Shi, W, Miranda, M, Kutasovic, J, Raghavendra, A, Madore, J, Reid, L, Krause, L, Chenevix-Trench, G, Lakhani, S R, Khanna, K K

Journal:

Year:

2014

File:

PDF, 53 KB

2014

13

Salivary miRNAome profiling uncovers epithelial and proliferative miRNAs with differential expression across dentition stages

Formosa, Amanda, Piro, Maria Cristina, Docimo, Raffaella, Maturo, Paolo, Sollecito, Daniela Rita Maria, Kalimutho, Murugan, Sancesario, Giulia, Barlattani, Alberto, Melino, Gerry, Candi, Eleanora, Ber

Journal:

Year:

2011

Language:

english

File:

PDF, 2.46 MB

english, 2011

14

Quantitative denaturing high performance liquid chromatography (Q-dHPLC) detection of APC long DNA in faeces from patients with colorectal cancer

Kalimutho, Murugan, Blanco, Giovanna Del Vecchio, Gravina, Paolo, Cretella, Micaela, Mannucci, Liliana, Mannisi, Elena, Formosa, Amanda, Pallone, Francesco, Federici, Giorgio, Bernardini, Sergio

Journal:

Clinical Chemistry and Laboratory Medicine

Year:

2010

Language:

english

File:

PDF, 389 KB

english, 2010

15

Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer

Al-Ejeh, F, Simpson, P T, Sanus, J M, Klein, K, Kalimutho, M, Shi, W, Miranda, M, Kutasovic, J, Raghavendra, A, Madore, J, Reid, L, Krause, L, Chenevix-Trench, G, Lakhani, S R, Khanna, K K

Journal:

Year:

2014

Language:

english

File:

PDF, 1.47 MB

english, 2014

16

Gemcitabine and CHK1 Inhibition Potentiate EGFR-Directed Radioimmunotherapy against Pancreatic Ductal Adenocarcinoma

Al-Ejeh, F., Pajic, M., Shi, W., Kalimutho, M., Miranda, M., Nagrial, A. M., Chou, A., Biankin, A. V., Grimmond, S. M., Brown, M. P., Khanna, K. K.

Journal:

Clinical Cancer Research

Year:

2014

Language:

english

File:

PDF, 1.93 MB

english, 2014

17

ADAM17-Dependent c-MET-STAT3 Signaling Mediates Resistance to MEK Inhibitors in KRAS Mutant Colorectal Cancer

Van Schaeybroeck, Sandra, Kalimutho, Murugan, Dunne, Philip D., Carson, Robbie, Allen, Wendy, Jithesh, Puthen V., Redmond, Keara L., Sasazuki, Takehiko, Shirasawa, Senji, Blayney, Jaine, Michieli, Pao

Journal:

Year:

2014

Language:

english

File:

PDF, 4.90 MB

english, 2014

18

Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis

Jeffery, J, Sinha, D, Srihari, S, Kalimutho, M, Khanna, K K

Journal:

Year:

2015

Language:

english

File:

PDF, 1.22 MB

english, 2015

19

Platinum-(IV)-derivative satraplatin induced G2/M cell cycle perturbation via p53-p21waf1/cip1-independent pathway in human colorectal cancer cells

Kalimutho, Murugan, Minutolo, Antonella, Grelli, Sandro, Federici, Giorgio, Bernardini, Sergio

Journal:

Acta Pharmacologica Sinica

Year:

2011

Language:

english

File:

PDF, 1.45 MB

english, 2011

20

Understanding the functional impact of copy number alterations in breast cancer using a network modeling approach

Srihari, Sriganesh, Kalimutho, Murugan, Lal, Samir, Singla, Jitin, Patel, Dhaval, Simpson, Peter T., Khanna, Kum Kum, Ragan, Mark A.

Journal:

Molecular BioSystems

Year:

2016

Language:

english

File:

PDF, 2.86 MB

english, 2016

21

Adenosine 2B receptor expression on cancer cells promotes metastasis

Mittal, D., Sinha, D., Barkauskas, D., Young, A., Kalimutho, M., Stannard, K., Caramia, F., Haibe-Kains, B., Stagg, J., Khanna, K. K., Loi, S., Smyth, M. J.

Journal:

Cancer Research

Year:

2016

Language:

english

File:

PDF, 4.17 MB

english, 2016

22

FBXO31 protects against genomic instability by capping FOXM1 levels at the G2/M transition

Jeffery, J M, Kalimutho, M, Johansson, P, Cardenas, D G, Kumar, R, Khanna, K K

Journal:

Year:

2016

Language:

english

File:

PDF, 2.23 MB

english, 2016

23

The metastasis suppressor RARRES3 as an endogenous inhibitor of the immunoproteasome expression in breast cancer cells

Anderson, Alison M., Kalimutho, Murugan, Harten, Sarah, Nanayakkara, Devathri M., Khanna, Kum Kum, Ragan, Mark A.

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 2.32 MB

english, 2017

24

Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae

Kalimutho, Murugan, Bain, Amanda L., Mukherjee, Bipasha, Nag, Purba, Nanayakkara, Devathri M., Harten, Sarah K., Harris, Janelle L., Subramanian, Goutham N., Sinha, Debottam, Shirasawa, Senji, Srihari

Journal:

Molecular Oncology

Year:

2017

Language:

english

File:

PDF, 923 KB

english, 2017

25

LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer

Boulding, T., McCuaig, R. D., Tan, A., Hardy, K., Wu, F., Dunn, J., Kalimutho, M., Sutton, C. R., Forwood, J. K., Bert, A. G., Goodall, G. J., Malik, L., Yip, D., Dahlstrom, J. E., Zafar, A., Khanna,

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 8.04 MB

english, 2018

26

CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer

Kalimutho, Murugan, Sinha, Debottam, Jeffery, Jessie, Nones, Katia, Srihari, Sriganesh, Fernando, Winnie C, Duijf, Pascal HG, Vennin, Claire, Raninga, Prahlad, Nanayakkara, Devathri, Mittal, Deepak, S

Journal:

EMBO Molecular Medicine

Year:

2018

Language:

english

File:

PDF, 3.85 MB

english, 2018

27

1663PTargeting thioredoxin reductase 1 in novel combination therapies in p53 mutant triple negative breast cancer

Raninga, P., Kalimutho, M., Sinha, D., Bain, A., Tonissen, K., Khanna, K.K.

Journal:

Annals of Oncology

Year:

2017

Language:

english

File:

PDF, 77 KB

english, 2017

28

Patterns of Genomic Instability in Breast Cancer

Kalimutho, Murugan, Nones, Katia, Srihari, Sriganesh, Duijf, Pascal H.G., Waddell, Nicola, Khanna, Kum Kum

Journal:

Trends in Pharmacological Sciences

Year:

2019

File:

PDF, 2.13 MB

2019

29

Patterns of Genomic Instability in Breast Cancer

Kalimutho, Murugan, Nones, Katia, Srihari, Sriganesh, Duijf, Pascal H.G., Waddell, Nicola, Khanna, Kum Kum

Journal:

Trends in Pharmacological Sciences

Year:

2019

Language:

english

File:

PDF, 2.13 MB

english, 2019

30

Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer

Kalimutho, Murugan, Sinha, Debottam, Mittal, Deepak, Srihari, Sriganesh, Nanayakkara, Devathri, Shafique, Shagufta, Raninga, Prahlad, Nag, Purba, Parsons, Kate, Khanna, Kum Kum

Journal:

Journal of Experimental & Clinical Cancer Research

Year:

2019

Language:

english

File:

PDF, 6.10 MB

english, 2019

31

MYB regulates the DNA damage response and components of the homology-directed repair pathway in human estrogen receptor-positive breast cancer cells

Yang, Ren-Ming, Nanayakkara, Devathri, Kalimutho, Murugan, Mitra, Partha, Khanna, Kum Kum, Dray, Eloise, Gonda, Thomas J.

Journal:

Year:

2019

File:

PDF, 2.44 MB

2019

32

Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti‐PD‐L1 antibody for treatment of triple‐negative breast cancer

Raninga, PV, Lee, A, Sinha, D, Shih, YY, Mittal, D, Makhale, A, Bain, A, Nanayakarra, D, Tonissen, KF, Kalimutho, M, Khanna, KK

Journal:

International Journal of Cancer

Year:

2019

File:

PDF, 3.45 MB

2019

33

7PDSynergistic anti-cancer activity of auranofin with anti-PD-L1 therapy in triple negative breast cancer

Raninga, P, Lee, A, Sinha, D, Shin, Y-Y, Mittal, D, Kalimutho, M, Khanna, K K

Journal:

Annals of Oncology

Year:

2019

File:

PDF, 75 KB

2019

34

Author Correction: LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer

Boulding, T., McCuaig, R. D., Tan, A., Hardy, K., Wu, F., Dunn, J., Kalimutho, M., Sutton, C. R., Forwood, J. K., Bert, A. G., Goodall, G. J., Malik, L., Yip, D., Dahlstrom, J. E., Zafar, A., Khanna,

Journal:

Scientific Reports

Year:

2019

File:

PDF, 617 KB

2019

35

Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition

Raninga, Prahlad V., Lee, Andy, Sinha, Debottam, Dong, Lan-feng, Datta, Keshava K., Lu, Xue, Kalita-de Croft, Priyakshi, Dutt, Mriga, Hill, Michelle, Pouliot, Normand, Gowda, Harsha, Kalimutho, Muruga

Journal:

Year:

2020

File:

PDF, 3.14 MB

2020

36

[BMJ Publishing Group Ltd Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June â 3 July 2018 - ()] Poster Presentation - Po-212âCEP55 over-expression causes genomic instability to initiate spontaneous tumour formation in vivo

Sinha, D, Kalimutho, M, Bain, AL, Khanna, KK

File:

PDF, 78 KB